About

Web service URL Source code
ClinOmicsTrailbc https://clinomicstrail.bioinf.uni-sb.de -
DrugTargetInspector https://dti.bioinf.uni-sb.de -
GeneTrail https://genetrail.bioinf.uni-sb.de C++ code for enrichment algorithms (https://github.com/unisb-bioinf/genetrail2)
NetworkTrail https://networktrail.bioinf.uni-sb.de C++ code for subgraph ILP (http://genetrail.bioinf.uni-sb.de/ilp/Home.html)
RegulatorTrail https://regulatortrail.bioinf.uni-sb.de -

ClinOmicsTrailbc

ClinOmicsTrailbc is an interactive visual analytics tool for breast cancer treatment stratification. ClinOmicsTrailbc offers rich functionality for the integration and analysis of clinical markers as well as transcriptomics and (epi-)genomics datasets with respect to a broad spectrum of biological, pharmacological, and medical knowledge. Our tool provides a comprehensive assessment of a variety of treatment options based on the tumor’s main driver mutations, the overall tumor mutational burden, activity patterns of core breast cancer-relevant pathways, drug-specific predictive biomarkers, the status of molecular drug targets and pharmacogenomic implications.

DrugTargetInspector

DrugTargetInspector (DTI) is an interactive assistance tool for treatment stratification. DTI analyzes genomic, transcriptomic and proteomic datasets and provides information on deregulated drug targets, enriched biological pathways and deregulated subnetworks, as well as mutations and their potential effects on putative drug targets and genes of interest. Please refer to our publication for further details and case studies (doi: 10.1002/ijc.29897).

GeneTrail

GeneTrail is a web-interface providing access to different tools for the statistical analysis of molecular signatures. GeneTrail allows the integrated analysis of transcriptomic, miRNomic, genomic, and proteomic datasets. It offers multiple statistical tests, a large number of predefined reference sets, as well as a comprehensive collection of biological categories and enables direct comparisons between the computed results.

NetworkTrail

NetworkTrail is a web-interface providing access to different analysis tools for regulatory networks.

RegulatorTrail

RegulatorTrail is a web-interface providing access to different methods to identify and prioritize key transcriptional regulators with respect to their impact on expression changes caused e.g. by pathological processes. All methods are based on different statistical tests and make use of our comprehensive collection of position count matrices (PCMs) and regulator-target gene interactions (RTIs) extracted from a variety of databases.